about:config then:
browser.cache.disk.enable    --> false
browser.cache.memory.enable  --> false

or use an addon like Toggle Cache: https://addons.mozilla.org/en-US/firefox/addon/togglecache/

browsers.reg

Windows Registry Editor Version 5.00
 
; ========================================
; FIREFOX OPTIMIZATIONS
; ========================================
 
[HKEY_CURRENT_USER\Software\Mozilla\Firefox]
 
"browser.cache.disk.enable"=dword:00000000
"browser.cache.memory.enable"=dword:00000000
"network.http.pipelining"=dword:00000001
"network.http.pipelining.maxrequests"=dword:00000008
"network.prefetch-next"=dword:00000000
"network.dns.disablePrefetch"=dword:00000001
"network.http.keep-alive.timeout"=dword:000003e8
 
; ========================================
; CHROME OPTIMIZATIONS
; ========================================
 
[HKEY_LOCAL_MACHINE\SOFTWARE\Policies\Google\Chrome]
 
; Disabilita cache predefinito
"DiskCacheSize"=dword:00000000
 
; Velocità di rete
"MaxConnectionsPerProxy"=dword:00000020
 
; Disabilita prefetch
"NetworkPredictionOptions"=dword:00000000
 
; Riduce memoria
"RendererCodeIntegrityEnabled"=dword:00000000
 
[HKEY_CURRENT_USER\Software\Google\Chrome\Default]
 
; Cancella cache all'uscita
"ClearBrowsingDataOnExit"=dword:00000001
 
; Disabilita preload pagine
"PreloadingEnabled"=dword:00000000
 
; ========================================
; EDGE OPTIMIZATIONS
; ========================================
 
[HKEY_LOCAL_MACHINE\SOFTWARE\Policies\Microsoft\Edge]
 
; Disabilita cache
"DiskCacheSize"=dword:00000000
 
; Disabilita prefetch
"NetworkPredictionOptions"=dword:00000000
 
; Velocità rete
"MaxConnectionsPerProxy"=dword:00000020
 
[HKEY_CURRENT_USER\Software\Microsoft\Edge\Default]
 
; Cancella cache all'uscita
"ClearBrowsingDataOnExit"=dword:00000001
 
; Disabilita preload
"PreloadingEnabled"=dword:00000000
 
; ========================================
; WINDOWS NETWORK OPTIMIZATIONS
; ========================================
 
[HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Services\Tcpip\Parameters]
 
"TcpWindowSize"=dword:00010000
"MaxMtu"=dword:00001500
"TcpAckFrequency"=dword:00000001
"DefaultTTL"=dword:00000040
"EnableTCPChimney"=dword:00000001
 
; ========================================
; DNS OPTIMIZATION
; ========================================
 
[HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Services\Dnscache\Parameters]
 
"CacheHashTableSize"=dword:00000100
"NegativeCacheTime"=dword:00000384
 
; ========================================
; WINDOWS DISK OPTIMIZATION
; ========================================
 
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\CurrentVersion\Explorer\VolumeCaches\Compress old files]
 
"StateFlags0001"=dword:00000002

browsers.reg

Windows Registry Editor Version 5.00
 
; DISABILITA TRADUZIONE AUTOMATICA - Chrome, Edge, Firefox
 
[HKEY_LOCAL_MACHINE\SOFTWARE\Policies\Google\Chrome]
"TranslateEnabled"=dword:00000000
 
[HKEY_CURRENT_USER\SOFTWARE\Policies\Google\Chrome]
"TranslateEnabled"=dword:00000000
 
[HKEY_LOCAL_MACHINE\SOFTWARE\Policies\Microsoft\Edge]
"TranslateEnabled"=dword:00000000
 
[HKEY_CURRENT_USER\SOFTWARE\Policies\Microsoft\Edge]
"TranslateEnabled"=dword:00000000
 
[HKEY_LOCAL_MACHINE\SOFTWARE\Policies\Mozilla\Firefox]
"TranslateEnabled"=dword:00000000
 
[HKEY_CURRENT_USER\SOFTWARE\Policies\Mozilla\Firefox]
"TranslateEnabled"=dword:00000000

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